Category: vaccines

The invention relates to protecting against Salmonella-type pathogens and more particularly, compositions and methods for immunizing against infection by typhoidal and non-typhoidal Salmonella serovars.

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Broad-spectrum antiviral compounds that inhibits pyrimidine biosynthesis, triggers innate immunity, and induces antiviral responses.

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Small molecule adjuvants that act as vaccine adjuvants by specifically binding to Toll-Like Receptor-8 (TLR8).

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The invention provides novel compounds (adjuvants) that can be used as agonists for Toll-Like Receptor 7 (TLR7).  By specifically targeting TLR7, these adjuvants elicit a type 1 interferon response which is essential in the development of antiviral responses.

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Novel chemical compounds for use as antivirals against VEEV and other alpha viruses.

Small molecule compounds that act as vaccine adjuvants by specifically binding to Toll-Like Receptor-2 (TLR2).  
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Using the mutated version of herpes simplex virus-1 (HSV1) to target and terminate CD133+ cancer stem cells.

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