This invention provides an improved method for producing a novel interfacing capillary device that is less costly and more durable than existing sheathless devices. This simplified production method does not require sample dilution, etching, or precision hand tools, and is automated and reproducible.
The small molecules in this work represent a novel composition of matter that can be used as either Kappa Opioid Receptor (KOR) agonists or antagonists. Further some of the compounds have been shown to weak agonists making them ideal to explore for the use of addiction.
This invention consists of a novel composition of matter as well as a process for the efficient conversion of glycerol to lactic acid.
This invention is a system to deliver poorly permeable molecules into mammalian cells and avoid the problem of degradation.
This invention is a novel composition of matter that facilitates delivery of agents (e.g. diagnostic, therapeutic, imaging, etc.) into cells
This invention utilizes a delivery system that allows for a biologically relevant moiety to be delivered to a desired cell by utilizing a transporting agent that binds two receptors expressed by that cell. This decreases the toxicity that is shown by the active compound by delivering it only to a targeted cell.
This invention is a novel composition of matter that disrupts endosomes allowing for the release of biologically active agents into the cytosol.