Category: biotechnology

The invention relates to protecting against Salmonella-type pathogens and more particularly, compositions and methods for immunizing against infection by typhoidal and non-typhoidal Salmonella serovars.

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This invention provides an improved method for producing a novel interfacing capillary device that is less costly and more durable than existing sheathless devices.  This simplified production method does not require sample dilution, etching, or precision hand tools, and is automated and reproducible.  

Regenerating and repairing individual organs and tissues for a single patient requires mass quantities of the patient’s own adult stem cells. Mass production of adult stem cells for therapeutic applications is highly limited due to the fact that adult stem cells have a limited shelf life when isolated from primary tissues of humans and animals. The act of removing adult stem cells from their original environment is traumatic and has the potential to induce changes or negative effects. Furthermore, the ability to grow adult stem cells in environments that mimic the original host tissue are limited. Adult stem cells lose “stemness” characteristics and the ability to divide and differentiate as adult stem cells are maintained and dissociated (passaged) from growth substrates, as is current practice.

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Use of a genetic dereplication strategy eliminates major known SM biosynthetic pathways in Aspergillus nidulans, reducing the complexity of SM profiles and activating an abundance of silent SM gene clusters to enable identification of a new pool of fungal products for drug discovery.

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The small molecules in this work represent a novel composition of matter that can be used as either Kappa Opioid Receptor (KOR) agonists or antagonists.  Further some of the compounds have been shown to weak agonists making them ideal to explore for the use of addiction.

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The invention describes CD44-selective nanovector systems for cancer-targeted delivery of molecular therapeutics.

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Broad based label-free systems identify protein stabilizers at physiological or near physiological conditions that specifically inhibit Bacterial Toxin or Viral entry into cells. 

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This invention is a tubular electrospun scaffold of natural protein gelatin and synthetic polyglycolic acid (PGA) / poly-lactic-co-glycolic (PLGA) polymers in a bioreactor system connected to a flow circuit and seeded with cultured fibroblasts and endothelial cells.

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Immuno-oncology represents the new wave of personalized medicine. Scientists at the University of Kansas have developed an innovative approach to activate intracellular signaling pathways that enhance T cell activation, expansion, and differentiation.

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PEPCK is an enzyme critical in the process of gluconeogenesis whose inhibition could be used to treat hyperglycemia and diabetes.

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