Category: research-tools

This invention combines the strengths of two commonly used mouse strains (C57BL/6J and FVB/N) to obtain a preferable nuclear genome amenable to pronuclear injection for mouse transgenesis.

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This invention provides an improved method for producing a novel interfacing capillary device that is less costly and more durable than existing sheathless devices.  This simplified production method does not require sample dilution, etching, or precision hand tools, and is automated and reproducible.  

Use of a genetic dereplication strategy eliminates major known SM biosynthetic pathways in Aspergillus nidulans, reducing the complexity of SM profiles and activating an abundance of silent SM gene clusters to enable identification of a new pool of fungal products for drug discovery.

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The present invention employs a novel use of logic and data analysis tools to improve the efficiency of drug discovery.

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A microfluidic device capable of efficiently isolating exosomes from blood and plasma.

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This invention consists of a new hyphenated atomic force microscopy (AFM) technique with whispering gallery mode sensing (WGM), which provides the ability to measure the topography and refractive index of a material simultaneously. 

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The ToP-SPA measures tongue-palate contact pressure occurring during speech and/or swallowing.

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Ecological Niche Modeling for Predicting the Potential Geographic Distribution of Invasive Species. This invention uses a novel combination of computer programs and analytical techniques drawn from quantitative geography, artificial intelligence, and the emerging field of biodiversity informatics to provide a tool for predicting, analyzing, and strategizing against agricultural species invasions.
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Hearing loss, tinnitus, and vertigo result from the damage of mechanosensory hair cells (HCs) located in sensory epithelium of the cochlea and vestibular organs of the inner ear. HCs do not regenerate. Currently, hearing aids and cochlear implants are the only treatments to address hearing loss, and both options provide mild relief. The challenge in developing new therapies and screening ototoxic agents is that the cochlear and vestibular sensory epithelium are isolated deep in the inner ear. Invasive measures are required to access the sensory epithelium. KU researchers have endeavored to create both cochlear and vestibular sensory epithelium outside of the body. They are developing a model platform where the cochlear and vestibular sensory epithelium can be grown outside of the body for testing and developing new diagnostics, screening ototoxic agents, and evaluating new therapies. No such model currently exists. Thus, this technology has the potential to take a leap forward in the advancement of medicine for hearing disorders.
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A novel sensor design allows capture of angular fluid flow with greater accuracy than the conventional Pitot-type probe currently in use in commercial and military aircraft

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