Category: biomarkers

This invention provides an improved method for producing a novel interfacing capillary device that is less costly and more durable than existing sheathless devices.  This simplified production method does not require sample dilution, etching, or precision hand tools, and is automated and reproducible.  

This invention is a molecular screen to predict which patients’ non-invasive breast tumors will eventually progress to invasive breast cancers.

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The current invention concerns the novel use of an endogenous estrogen derivative that has a super-strong neuroprotective effect against oxidative neurotoxicity in vivo.

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A microfluidic device capable of efficiently isolating exosomes from blood and plasma.

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Hearing loss, tinnitus, and vertigo result from the damage of mechanosensory hair cells (HCs) located in sensory epithelium of the cochlea and vestibular organs of the inner ear. HCs do not regenerate. Currently, hearing aids and cochlear implants are the only treatments to address hearing loss, and both options provide mild relief. The challenge in developing new therapies and screening ototoxic agents is that the cochlear and vestibular sensory epithelium are isolated deep in the inner ear. Invasive measures are required to access the sensory epithelium. KU researchers have endeavored to create both cochlear and vestibular sensory epithelium outside of the body. They are developing a model platform where the cochlear and vestibular sensory epithelium can be grown outside of the body for testing and developing new diagnostics, screening ototoxic agents, and evaluating new therapies. No such model currently exists. Thus, this technology has the potential to take a leap forward in the advancement of medicine for hearing disorders.
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Currently there are no good treatment options for individuals diagnosed with pancreatic cancer. As a result, the two year survival rate after diagnosis is only 10%. Thus, novel therapeutic agents are needed that effectively treat pancreatic cancer.
 
The current invention is novel crocetinic analogs that have showed reduced proliferation of pancreatic cancer cells and inhibited metastasis in pancreatic cancer mouse model. These analogs carry out this function by targeting key factors that function in pancreatic cancer tumor growth. The analogs are stable and non-toxic.
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The invention offers novel composition of matter to be used in treatment of a number of hormone responsive cancers.

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A novel method of inducing adult-derived stem cell proliferation in tissue from adult animals. Harvested embryonic, pluripotent or more differentiated stem cells may be used in cell therapy, tissue engineering, or other medical, veterinary, and industrial applications.

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The invention provides a "sample-in-answer-out" microfluidic exosome profiling platform which integrates immunoaffinity isolation of plasma exosomes with quantitative detection of both surface and intravesicular markers for characterization of exosomal phenotypes. 

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This invention uses microRNA biomarkers to detect or diagnose Barrett's esophagus, detect dysplasia in Barrett's esophagus, and detect early onset of esophageal cancer.

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