This invention provides an improved method for producing a novel interfacing capillary device that is less costly and more durable than existing sheathless devices. This simplified production method does not require sample dilution, etching, or precision hand tools, and is automated and reproducible.
Use of a genetic dereplication strategy eliminates major known SM biosynthetic pathways in Aspergillus nidulans, reducing the complexity of SM profiles and activating an abundance of silent SM gene clusters to enable identification of a new pool of fungal products for drug discovery.
Broad based label-free systems identify protein stabilizers at physiological or near physiological conditions that specifically inhibit Bacterial Toxin or Viral entry into cells.
PEPCK is an enzyme critical in the process of gluconeogenesis whose inhibition could be used to treat hyperglycemia and diabetes.
The present invention employs a novel use of logic and data analysis tools to improve the efficiency of drug discovery.
The current invention is a novel class of compounds that function as KOR antagonists. Because KOR activation has been linked to depression and anxiety related disorders, this novel class of compounds may be used in the development of therapies to treat these mental disorders
The invention offers novel composition of matter to be used in treatment of a number of hormone responsive cancers.
The invention offers high load reagents and scavengers which combine the physical properties of the silica surface with the inherent tunable properties of the ROMP-derived oligomers.