Category: therapeutics

The invention relates to protecting against Salmonella-type pathogens and more particularly, compositions and methods for immunizing against infection by typhoidal and non-typhoidal Salmonella serovars.

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The invention consists of compounds for the treatment of parasitic diseases such as Trypanosomiasis and Leishmaniasis.  Compounds are first-in-class, and selectively targeted towards pathogenic cells with nanomolar potency.

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This invention describes the first selective inhibitor of heat shock protein 90 kDa beta (Hsp90β). The invented inhibitor selectively binds to the N-terminus of Hsp90β and may be developed for the treatment of cancers. The inhibitor was developed based on the sequence alignment of the N-terminal ATP-binding domains of Hsp90α and Hsp90β complexed with a non-selective Hsp90 inhibitor, which revealed Hsp90β-specific residues that were key to exploit the selectivity of the new inhibitor. 

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Structural modification of a non-selective aminocyclohexanol-based heat shock protein 90 KDa (Hsp90) inhibitor led to a highly selective inhibitor of glucose regulated protein 94 kDa (Grp94). The new Grp94-selective inhibitor can be used to develop an effective therapy for the treatment of metastatic cancer and/or primary open angle glaucoma (POAG).

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Use of a genetic dereplication strategy eliminates major known SM biosynthetic pathways in Aspergillus nidulans, reducing the complexity of SM profiles and activating an abundance of silent SM gene clusters to enable identification of a new pool of fungal products for drug discovery.

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This invention is a molecular screen to predict which patients’ non-invasive breast tumors will eventually progress to invasive breast cancers.

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Selective heat shock protein 90 (Hsp90) and glucose regulated protein 94 (Grp94) inhibitors that can be used to develop an effective therapy for treating primary open angle glaucoma (POAG).

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The small molecules in this work represent a novel composition of matter that can be used as either Kappa Opioid Receptor (KOR) agonists or antagonists.  Further some of the compounds have been shown to weak agonists making them ideal to explore for the use of addiction.

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The invention describes CD44-selective nanovector systems for cancer-targeted delivery of molecular therapeutics.

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This invention is a tubular electrospun scaffold of natural protein gelatin and synthetic polyglycolic acid (PGA) / poly-lactic-co-glycolic (PLGA) polymers in a bioreactor system connected to a flow circuit and seeded with cultured fibroblasts and endothelial cells.

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