Category: assays

This invention provides an improved method for producing a novel interfacing capillary device that is less costly and more durable than existing sheathless devices.  This simplified production method does not require sample dilution, etching, or precision hand tools, and is automated and reproducible.  

This invention is a molecular screen to predict which patients’ non-invasive breast tumors will eventually progress to invasive breast cancers.

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A microfluidic device capable of efficiently isolating exosomes from blood and plasma.

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This invention consists of a new hyphenated atomic force microscopy (AFM) technique with whispering gallery mode sensing (WGM), which provides the ability to measure the topography and refractive index of a material simultaneously. 

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Hearing loss, tinnitus, and vertigo result from the damage of mechanosensory hair cells (HCs) located in sensory epithelium of the cochlea and vestibular organs of the inner ear. HCs do not regenerate. Currently, hearing aids and cochlear implants are the only treatments to address hearing loss, and both options provide mild relief. The challenge in developing new therapies and screening ototoxic agents is that the cochlear and vestibular sensory epithelium are isolated deep in the inner ear. Invasive measures are required to access the sensory epithelium. KU researchers have endeavored to create both cochlear and vestibular sensory epithelium outside of the body. They are developing a model platform where the cochlear and vestibular sensory epithelium can be grown outside of the body for testing and developing new diagnostics, screening ototoxic agents, and evaluating new therapies. No such model currently exists. Thus, this technology has the potential to take a leap forward in the advancement of medicine for hearing disorders.
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A three-dimensional tumor-in-dish (TID) cell-based assay kit for cancer drug screening that closely replicates actual cellular microenvironments and, therefore, can determine which compounds to move forward for in vivo testing. 

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Novel chemical compounds for use as antivirals against RSV

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The invention provides a "sample-in-answer-out" microfluidic exosome profiling platform which integrates immunoaffinity isolation of plasma exosomes with quantitative detection of both surface and intravesicular markers for characterization of exosomal phenotypes. 

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The invention offers high load reagents and scavengers which combine the physical properties of the silica surface with the inherent tunable properties of the ROMP-derived oligomers.

The invention entails solution conditions that can prolong the recovery and foldability of proteins under non-denaturing conditions in the presence of the tetradecameric GroEL chaperonin. 

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