Platform Technology for Creating Cochlea for Drug Testing
We are developing a fully functional ex vivo (outside of body) cochlear and vestibular sensory epithelium model that can be licensed out to use for studying inner ear pathologies, developing new diagnostics for hearing loss, screening ototoxic agents (e.g., antibiotics, cancer drugs), and testing new therapeutics (e.g., gene vectors, stem cell transplantation, drugs)
Drug Screening, Gene Therapy Testing, and Stem Cell Therapy Evaluation
How it works:
Instructions and markers are available on how to assemble and use the materials and cells to grow the cochlear and vestibular sensory epithelium to use for testing and development purposes.
The technology can be used for testing new pharmaceuticals and other therapies for ototoxicity and/or HC healing. Using this product in early development stages instead of needing to run several animal studies to determine the effectiveness of a pharmaceutical can save huge costs. Clients can develop their own pharmaceuticals, diagnostic tools, and therapies off of this model.
Why it is better:
Currently, there is no ex vivo model for cochlear and vestibular sensory epithelium. Thus, investigators have to use small animals to evaluate pharmaceuticals. Additionally, animals need to be sacrificed to obtain the cochlea and vestibular organ to analyze results. With this product, there is no need to use animals. The sensory epithelium of the cochlea and vestibular system are grown outside of the body for real-time testing.
The technology could potentially be adapted for growing other organ systems that are difficult to study outside of the body.